Harry Holthöfer Selected Research

nephrin

5/2012	Transcription of nephrin-Neph3 gene pair is synergistically activated by WT1 and NF-κB and silenced by DNA methylation.
8/2011	Nephrinuria associates with multiple renal traits in type 2 diabetes.
1/2007	Circulating antibodies to nephrin in patients with type 1 diabetes.
1/2006	Molecular basis of the glomerular filtration: nephrin and the emerging protein complex at the podocyte slit diaphragm.
9/2004	Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin.
7/2004	Stable expression of nephrin and localization to cell-cell contacts in novel murine podocyte cell lines.
6/2004	Molecular cloning and characterization of an endogenous antisense transcript of Nphs1.
5/2003	Inflammatory cytokines upregulate nephrin expression in human embryonic kidney epithelial cells and podocytes.
7/2002	Expression of the slit-diaphragm protein, nephrin, in experimental diabetic nephropathy: differing effects of anti-proteinuric therapies.
6/2002	Nephrin TRAP mice lack slit diaphragms and show fibrotic glomeruli and cystic tubular lesions.

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Harry Holthöfer Research Topics

Disease

6	Proteinuria 07/2007 - 01/2002
5	Nephrotic Syndrome (Syndrome, Nephrotic) 01/2006 - 06/2002
4	Abdominal Obesity 01/2016 - 01/2013
4	Albuminuria 01/2013 - 12/2004
3	Hypertension (High Blood Pressure) 01/2016 - 06/2014
3	Diabetic Nephropathies (Diabetic Nephropathy) 06/2014 - 07/2002
2	Inflammation (Inflammations) 01/2022 - 01/2013
2	Infections 01/2019 - 12/2002
2	Renal Insufficiency (Renal Failure) 01/2017 - 12/2004
2	Chronic Renal Insufficiency 01/2016 - 01/2013
2	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 02/2007 - 01/2007
2	Nephrosis 01/2003 - 06/2002
1	Thrombosis (Thrombus) 01/2022
1	Hantavirus Infections 01/2019
1	Coronary Disease (Coronary Heart Disease) 01/2016
1	Non-alcoholic Fatty Liver Disease 09/2014
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 03/2014
1	Necrosis 05/2012
1	Edema (Dropsy) 01/2012
1	Insulin Resistance 10/2010
1	Focal Segmental Glomerulosclerosis (Glomerulosclerosis, Focal) 07/2007
1	Kidney Diseases (Kidney Disease) 01/2007
1	Wilms Tumor (Wilm's Tumor) 07/2004
1	Hypercholesterolemia 01/2003
1	Epstein-Barr Virus Infections 12/2002
1	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2002
1	Membranoproliferative Glomerulonephritis (Membranoproliferative Glomerulonephritis, Type II) 01/2002
1	Nephritis 01/2002
1	Membranous Glomerulonephritis (Membranous Nephropathy) 01/2002

Drug/Important Bio-Agent (IBA)

11	nephrinIBA 05/2012 - 01/2002
5	Proteins (Proteins, Gene)FDA Link 01/2007 - 01/2002
4	CreatinineIBA 09/2014 - 07/2007
3	AntigensIBA 01/2019 - 01/2007
3	AlbuminsIBA 09/2014 - 08/2011
3	Glucose (Dextrose)FDA LinkGeneric 09/2014 - 08/2013
3	Messenger RNA (mRNA)IBA 05/2012 - 07/2007
2	Triglycerides (Triacylglycerol)IBA 06/2014 - 08/2013
2	Insulin (Novolin)FDA Link 10/2010 - 01/2007
2	AutoantibodiesIBA 02/2007 - 01/2007
2	AntibodiesIBA 01/2007 - 01/2002
2	Puromycin AminonucleosideIBA 01/2003 - 06/2002
1	GlycosaminoglycansIBA 01/2022
1	Hemostatics (Antihemorrhagics)IBA 01/2022
1	Protein CIBA 01/2022
1	Immunoglobulin Light Chains (Immunoglobulin Light Chain)IBA 01/2019
1	CD2-associated proteinIBA 01/2017
1	ORALIT (ORS)IBA 01/2016
1	Indicators and Reagents (Reagents)IBA 01/2016
1	HDL LipoproteinsIBA 09/2014
1	Streptozocin (Streptozotocin)FDA Link 06/2014
1	Uric Acid (Urate)IBA 03/2014
1	HDL CholesterolIBA 08/2013
1	C-Reactive ProteinIBA 01/2013
1	MorpholinosIBA 01/2012
1	UromodulinIBA 08/2011
1	pantetheinase (pantetheine hydrolase)IBA 08/2011
1	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 07/2007
1	AutoantigensIBA 02/2007
1	Glutamate Decarboxylase (Decarboxylase, Glutamate)IBA 01/2007
1	Protein Tyrosine PhosphatasesIBA 01/2007
1	NPHS2 proteinIBA 01/2007
1	CalciumIBA 12/2004
1	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 12/2004
1	Phosphates (Orthophosphate)IBA 12/2004
1	SaltsIBA 12/2004
1	podocalyxinIBA 07/2004
1	Probucol (Lorelco)FDA Link 01/2003
1	CholesterolIBA 01/2003
1	PuromycinIBA 01/2003
1	Apolipoproteins E (ApoE)IBA 01/2003
1	ApolipoproteinsIBA 01/2003
1	ParaproteinsIBA 12/2002
1	pimagedine (aminoguanidine)IBA 07/2002
1	Membrane Proteins (Integral Membrane Proteins)IBA 07/2002
1	Pharmaceutical PreparationsIBA 07/2002
1	EpitopesIBA 01/2002

Therapy/Procedure

1	Therapeutics 07/2002